Hydrochloric Acid → HCID 12899692, compound

Participants

Reaction Steps

2.0 g of 8-(1-piperazinyl)-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid was added to 20 ml of water having dissolved therein 2.0 g of potassium carbonate and the mixture was stirred at room temperature for 30 minutes. After dissolving insoluble materials completely with the addition of 3 ml of 1 N aqueous sodium hydroxide solution, 10 ml of methanol having dissolved therein 0.9 g of benzyl chloride was added dropwise to the mixture while ice-cooling. After completion of the addition, the resulitng mixture was heat-refluxed for 3 hours to form a uniform solution. The solution obtained was treated with activated carbon while hot and rendered neutral with a 10% aqueous hydrochloric acid to precipitate crystals, which were separated by filtration and washed with water. Recrystallization of the crystals thus treated from dimethylformamide gave 0.25 g of 8-(4-benzyl-1-piperazinyl)-6,7-dihydro-1-oxo-1H,5H-benzo[ij]-quinolizine-2-carboxylic acid having a melting point of 274° to 278° C.

Provenance & Evidence