1-Piperazinecarboxaldehyde → HCID 13269519, compound

HRID 1649448Notes

Reaction equation

Cl[C:2]1[C:13]2=[C:14]3[N:9]([CH:10]([CH3:15])[CH2:11][CH2:12]2)[CH:8]=[C:7]([C:16]([OH:18])=[O:17])[C:6](=[O:19])[C:5]3=[CH:4][CH:3]=1.[CH:20]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)=[O:21]>>[CH:20]([N:22]1[CH2:27][CH2:26][N:25]([C:2]2[C:13]3=[C:14]4[N:9]([CH:10]([CH3:15])[CH2:11][CH2:12]3)[CH:8]=[C:7]([C:16]([OH:18])=[O:17])[C:6](=[O:19])[C:5]4=[CH:4][CH:3]=2)[CH2:24][CH2:23]1)=[O:21]

Participants

Reactant 2

HCID 821911-Piperazinecarboxaldehyde

HCID 20259004HCID 20259004, compound

Product 1

HCID 13269519HCID 13269519, compound

Procedure

In an analogous manner as in Example 1, 8-chloro-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]-quinolizine-2-carboxylic acid was reacted with 1-formylpiperazine to form 8-(4-formyl-1-piperazinyl)-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid as white rhombic crystals having a melting point of 300° C. or more.

Sources & evidence

ORD record: ord-70ca92978aa245f2a5c0799443104fe8
Source dataset: uspto-grants-1983_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04416884

Reaction notes

Loading…