HCID 13251304, compound → Isoxepac

Participants

Reaction Steps

A mixture containing 6,11-dihydro-α-chloro-11-oxodibenz[b,e]oxepin-2-acetic acid in the amount of 0.2 grams, 0.2 grams of 5% palladium-carbon reduction catalyst, 30 ml ethyl acetate and commercially available 4Å molecular sieve (Davidson Grade 514, Type 4A, 8-12 mesh beads, alumina silicate base with sodium cation, available from W. R. Grace) was treated with hydrogen (10 psi). The reduction reaction was run for 4 hours and then worked up by filtration and concentration in vacuo to yield 0.18 grams of crude product. 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid (V) was obtained after purification by chromatography on silica gel using ethyl acetate. Its structure was confirmed by comparison of its infra-red, proton-NMR and thin layer chromatography with that of an authentic sample.

Provenance & Evidence