HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → N-methyl-N-(phenylmethoxy)-2-nitrobenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-(Benzyloxy)-2-nitrobenzenesulfonamide | HCID 9839578 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | N-methyl-N-(phenylmethoxy)-2-nitrobenzenesulfonamide | HCID 20478825 | 76.9% |
Reaction Steps
A mixture of 110.6 g of the product of Example 32, 49.8 g of anhydrous potassium carbonate, 55.8 g of methyliodide and 500 ml of acetone was stirred at ambient temperature for 20 hours. The solvent was evaporated and the residue partitioned between methylene chloride and water. Concentration of the organic extract afforded 88.9 g of N-methyl-N-(phenylmethoxy)-2-nitrobenzenesulfonamide as a yellow oil. [NMR: δ 2.8 (s, 3H, NCH3)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04417917 |
| Source dataset | uspto-grants-1983_11 |
| ORD ID | ord-ebfc55d529b845bd9b39e3a1dd19f3c7 |
| Source note | uspto-grants-1983_11 |