反应详情

A solution of crude 1-(4-chlorophenyl)-1-(3-pyridyl)-2-propen-1-ol (40 mmol) in 100 ml methylene chloride was added dropwise to a suspension of phosphorus pentachloride (12.4 g, 60 mmol) at 10° C. After stirring for 1 h at room temperature the solution was washed with 50 ml water at 0° to 10° C. The solution of the crude title compound was used in the following aminations, i.e. Example 2 and 3.

1. washwas washed with 50 ml water at 0° to 10° C