HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Chlorophenyl)-3-(3-pyridyl)-2-propen-1-ol → 3-(4-Chlorophenyl)-3-(3-pyridyl)-2-propenal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Chlorophenyl)-3-(3-pyridyl)-2-propen-1-ol | HCID 53791953 | — |
| Catalyst | HCID 178418406 | HCID 178418406 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3-(4-Chlorophenyl)-3-(3-pyridyl)-2-propenal | HCID 54326173 | 100.8% |
Reaction Steps
A mixture of 0.30 g 3-(4-chlorophenyl)-3-(3-pyridyl)-2-propen-1-ol and 1.5 g manganese dioxide in 15 ml chloroform was stirred overnight at room temperature under nitrogen. Filtration and evaporation of the solvent gave 0.30 g of a yellow oil, which contained the isomeric aldehydes in a Z/E ratio of circa 60/40 according to NMR. The crude product was used directly in the reductive dimethylamination according to Example 15.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04418065 |
| Source dataset | uspto-grants-1983_11 |
| ORD ID | ord-9ecc444cc209468e8b37b6e4fda436d5 |
| Source note | uspto-grants-1983_11 |