Water ethanol → HCID 20479083, compound

Participants

Reaction Steps

A mixture of 2,4-difluoro 3-benzylaminobutyric acid, hydrochloride prepared as in Step C (1.010 g, 3.84 mM) and 5% palladium on charcoal (type H, 0.150 g) in glacial acetic acid (30 ml) is shaken under hydrogen (60 psi) in a Parr hydrogenator for 16 hours at room temperature. Filtration of the catalyst, and removal of the solvent in vacuo yield a colourless oil. A first crystal crop was isolated by crystallisation from water/ethanol (0.185 g). A second crystal crop was obtained by passing the mother liquors on an ion exchange column (Dowex 50, H+, eluted with water) (0.190 g). Overall yield about 70%.

Provenance & Evidence