Hydrochloric Acid → HCID 19854191, compound

Participants

Reaction Steps

Zinc chloride (7.1 g) was added to pyridine (50 ml) followed by 4-phenylcyclohexane-1,3-dione (5 g). n-Butyryl chloride (2.6 g) was then added dropwise and the mixture heated to reflux for 4 hours. After cooling, the mixture was poured into 5N hydrochloric acid (200 ml) and the aqueous phase extracted with methylene chloride. The extracts were dried over magnesium sulphate, filtered and evaporated to give a red oil. Purification on a silica gel column using methylene chloride as eluent gave the title compound as an orange oil (2.15 g).

Provenance & Evidence