HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → HCID 14013806, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 3-Ethyl 5-methyl 4-chloro-6-(chlorodifluoromethyl)-2-(trifluoromethyl)-3,5-pyridinedicarboxylate | HCID 14013759 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 14013806 | HCID 14013806 | 115.8% |
Reaction Steps
This compound was prepared as described in Example 37: 6.0 g (0.015 mol) of product of Example 28, 2.1 ml (0.030 mol) of cyclopropylamine in 25 ml of DMF were reacted at room temperature affording 7.24 g of oil. Purification by HPLC using 5% ethyl acetate/cyclohexane as eluting solvent afforded 4.77 g of solid which was recrystallized in hot hexane to give 3.92 g (62.7%) of product as a beige solid; mp 72°-73.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04921530 |
| Source dataset | uspto-grants-1990_05 |
| ORD ID | ord-19baa7c4dd6a436e9268326322a9c9f5 |
| Source note | uspto-grants-1990_05 |