HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 14013825, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Glycine ethyl ester, hydrochloride | HCID 2723640 | — |
| Reactant | 3-Ethyl 5-methyl 4-chloro-6-(chlorodifluoromethyl)-2-(trifluoromethyl)-3,5-pyridinedicarboxylate | HCID 14013759 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 14013825 | HCID 14013825 | 82.4% |
Reaction Steps
This compound was prepared as described in Example 37: 5.0 g (0.013 mol) of product of Example 28, 1.82 g (0.013 mol) of ethyl glycinate hydrochloride, 2.63 g (0.026 mol) of triethylamine in 30 ml of DMF were reacted at room temperature for 16 hours affording a residue which was kugelrohr distilled at 67 Pa, pot temperature 150° C., to give 4.96 g of solid. Recrystallization in hot hexane afforded 4.60 g (75.3%) of product as a beige solid; mp 60°-61.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04921530 |
| Source dataset | uspto-grants-1990_05 |
| ORD ID | ord-5c83f2f2a4df4ae0a9421a8b0cd251ef |
| Source note | uspto-grants-1990_05 |