HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 14013819, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,2,3,3,3-Pentafluoropropylamine | HCID 79002 | — |
| Reactant | 3-Ethyl 5-methyl 4-chloro-6-(chlorodifluoromethyl)-2-(trifluoromethyl)-3,5-pyridinedicarboxylate | HCID 14013759 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 14013819 | HCID 14013819 | 81.1% |
Reaction Steps
This compound was prepared as described in Example 37: 5.0 g (0.013 mol) of product of Example 28, 1.94 g (0.013 mol) of 2,2,3,3,3-pentafluoropropylamine, 1.81 ml (0.013 mol) of triethylamine in 30 ml of DMF were reacted at 50° C. for 64 hours, affording 5.36 g of oil. This oil was purified by HPLC using 1% ethyl acetate/cyclohexane as eluting solvent to give 1.82 g of oil which was kugelrohr distilled at 41 Pa, pot temperature 95° C., to give 1.55 g (23.4%) of product as a clear oil, nD25 1.4351.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04921530 |
| Source dataset | uspto-grants-1990_05 |
| ORD ID | ord-9de96c6b34e94b359c8123e4b12b3857 |
| Source note | uspto-grants-1990_05 |