Acrylic Acid → HCID 178433749, compound

Participants

Reaction Conditions

Reaction Steps

23 g 3-[3-(4-aminophenoxy)-propyl]-6-methyl-7-chloro-1H-pyrazolo[5,1-c]-1,2,4-triazole and 10.8 g acrylic acid are dissolved in dimethyl acetamide heated to 85° C. and are stirred at that temperature for 1 hour. The reaction mixture is then poured onto 300 g of an ice/water mixture, the deposit precipitated is filtered off under suction and recrystallized from ethyl acetate. 3-[3-(4-carboxyethylaminophenoxy)-propyl]-6-methyl-7-chloro-1H-pyrazolo-[5,1-c]-1,2,4-triazole melting at 151° to 153° C. is obtained in a yield of 61%.

Provenance & Evidence