Water → HCID 14748414, compound

Participants

Reaction Steps

A mixture of 2-benzyl-4-chloropyridine (0.480 q; see Example 1) and N-methylpiperazine (1.0 ml) is heated at 125° under an inert atmosphere for 17 hours. Upon cooling to room temperature, the mixture produces a crystalline mass. The crude solid is treated with saturated aqueous potassium carbonate (5 ml), water (2 ml), diethyl ether (5 ml) and dichloromethane (5 ml). The organic layer is separated, dried and concentrated to an oil. Excess N-methylpiperazine is removed by drying the oil at 45° under high vacuum (10 torr), giving the title compound as a viscous oil. Structure assignment is confirmed by nmr spectroscopy. nmr (CDCl3): δ (ppm) 2.34 (s, 3H); 2.48 (dd, 4H); 3.28 (dd, 4H); 4.07 (s, 2H); 6.5 (m, 3H); 7.26 (m, 4H); 8.22 (d, 1H).

Provenance & Evidence