HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 6-(Imidazol-1-ylacetyl)-3,4-dihydrocarbostyril
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 6-(2-Chloroacetyl)-1,2,3,4-tetrahydroquinolin-2-one | HCID 4961790 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-(Imidazol-1-ylacetyl)-3,4-dihydrocarbostyril | HCID 14207262 | — |
Reaction Steps
A solution of 9.0 g of 6-(chloroacetyl)-3,4-dihydrocarbostyril and 13.4 g of imidazole in 40 ml of N,N-dimethylformamide was heated at 80° C. for 18 hours. The reaction mixture was diluted with 1000 ml of water and the precipitate filtered off, washed with water followed by a little acetone and dried under vacuum to afford 6-[(imidazol-1-yl)acetyl]-3,4-dihydrocarbostyril, having a melting point of 269°-273° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04921862 |
| Source dataset | uspto-grants-1990_05 |
| ORD ID | ord-2e92f9d25ec4494eb9611dc8fd86a8b1 |
| Source note | uspto-grants-1990_05 |