6-[3-(Imidazol-1-yl)prop-1-yn-1-yl]-3,4-dihydrocarbostyril → 6-[3-(Imidazol-1-yl)prop-1-en-1-yl]-3,4-dihydrocarbostyril

HRID 1649742노트

반응식

HRID 1649742 반응식
[N:1]1([CH2:6][C:7]#[C:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[NH:15][C:14](=[O:19])[CH2:13][CH2:12]3)[CH:5]=[CH:4][N:3]=[CH:2]1.[H][H]>[Pd].N1C=CC=CC=1>[N:1]1([CH2:6][CH:7]=[CH:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[NH:15][C:14](=[O:19])[CH2:13][CH2:12]3)[CH:5]=[CH:4][N:3]=[CH:2]1

참가 물질

5

반응물 2

HCID 143732826-[3-(Imidazol-1-yl)prop-1-yn-1-yl]-3,4-dihydrocarbostyrilHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 537011596-[3-(Imidazol-1-yl)prop-1-en-1-yl]-3,4-dihydrocarbostyril

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 1049Pyridine용매2회

실험 절차

A suspension of 75 mg of 5% palladium on barium sulfate catalyst in 8 ml of pyridine was stirred under hydrogen for 15 minutes. A solution of 502 mg of 6-[3-(imidazol-1-yl)prop-1-yn-1-yl]-3,4-dihydrocarbostyril in 3 ml of pyridine was added and the mixture stirred under hydrogen until the theoretical volume of hydrogen had been absorbed. The reaction mixture was filtered and the solvent removed from the filtrate under reduced pressure to give a residue which was recrystallized from a mixture of methanol and ethyl acetate to give 6-[3-(imidazol-1-yl)prop-1-en-1-yl]-3,4-dihydrocarbostyril, m.p. 158°-160° C.

후처리

  1. customhad been absorbed
  2. filtrationThe reaction mixture was filtered
  3. customthe solvent removed from the filtrate under reduced pressure
  4. customto give a residue which
  5. customwas recrystallized from a mixture of methanol and ethyl acetate

출처 및 근거

ORD 기록
ord-69a798dc50734e6da4c44363b2d9d5a7
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04921862

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