Sodium Hydroxide → 6-[3-(Imidazol-1-yl)propyl]-3,4-dihydrocarbostyril

HRID 1649749Notes

Reaction equation

HRID 1649749 reaction equation
Cl.[N:2]1([CH2:7][CH2:8][CH2:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14][CH2:13]3)[CH:6]=[CH:5][N:4]=[CH:3]1.[OH-].[Na+]>C(Cl)Cl>[N:2]1([CH2:7][CH2:8][CH2:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14][CH2:13]3)[CH:6]=[CH:5][N:4]=[CH:3]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 198547386-[3-(Imidazol-1-yl)propyl]-3,4-dihydrocarbostyril hydrochloride

Product 1

HCID 143732856-[3-(Imidazol-1-yl)propyl]-3,4-dihydrocarbostyril

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A suspension of 1.0 g of 6-[3-(imidazol-1-yl)propyl]-3,4-dihydrocarbostyril hydrochloride in 100 ml of methylene chloride is stirred with a twofold stoichiometric excess of dilute aqueous sodium hydroxide solution until the salt is completely dissolved. The organic layer is separated, washed with water, dried over magnesium sulfate and evaporated to yield 6-[3-(imidazol-1-yl)propyl]-3,4-dihydrocarbostyril as the free base.

Workup

  1. dissolutionis completely dissolved
  2. customThe organic layer is separated
  3. washwashed with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-61c8944e9f634f528fc3ca0bceb609f2
Source dataset
uspto-grants-1990_05
Patent number
US04921862

Reaction notes

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