Diethyl Ether → HCID 14456853, compound

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Reaction Steps

In a mixture of 50 ml of ethanol and 7.1 ml of dioxane is dissolved 4.46 g of ethyl 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(4-tert-butoxycarbonylaminobutoxyimino)acetate, followed by addition of 7.1 ml of 2 N-aqueous sodium hydroxide solution. The mixture is stirred at room temperature for 10 hours. To this reaction mixture was added 500 ml of ether and the resulting precipitates are collected by filtration. The precipitate is dissolved in water and under ice-cooling the solution is adjusted to p 2 with 3 N-HCl and extracted with ethyl acetate. The extract is washed with aqueous sodium chloride solution and dried over magnesium sulfate, and the solvent is distilled off under reduced pressure. To the residue is added ether-petroleum ether (1:3) and the resulting light yellow powders are collected by filtration. The above procedure yields 4.01 g of 2-(2-tritylaminothiazol-4-yl)-(Z)- 2-(4-tert-butoxycarbonylaminobutoxyimino)acetic acid.

Provenance & Evidence