HCID 19854389, compound → HCID 19854390, compound

HRID 1649767Notes

Reaction equation

HRID 1649767 reaction equation
Cl.Cl.[NH2:3][CH2:4][CH2:5][S:6][C:7]1[CH:8]=[CH:9][C:10]2[N:11]([CH:13]=[CH:14][N:15]=2)[N:12]=1>[OH-].[Na+]>[NH2:3][CH2:4][CH2:5][S:6][C:7]1[CH:8]=[CH:9][C:10]2[N:11]([CH:13]=[CH:14][N:15]=2)[N:12]=1

Participants

3

Reactant 1

HCID 19854389HCID 19854389, compound

Product 1

HCID 19854390HCID 19854390, compoundYield 97.1%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To 50 ml of 3N aqueous sodium hydroxide solution is added 10.69 g of 6-(2-aminoethylthio)imidazo[1,2-b]pyridazine dihydrochloride and the mixture is stirred and, then, extracted with chloroform twice (150 ml and 50 ml). The extracts are combined and dried over magnesium sulfate and the solvent is distilled off under reduced pressure to give 7.55 g of 6-(2-aminoethylthio)imidazo[1,2-b]pyridazine as light yellow crystals.

Workup

  1. extractionextracted with chloroform twice (150 ml and 50 ml)
  2. dry with materialdried over magnesium sulfate
  3. distillationthe solvent is distilled off under reduced pressure

Sources & evidence

ORD record
ord-e85badb89e3b45dabfc8e3805905fa40
Source dataset
uspto-grants-1990_05
Patent number
US04921851

Reaction notes

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