Formaldehyde → HCID 14280682, compound

HRID 1649776Notes

Reaction equation

HRID 1649776 reaction equation
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[ClH:12].[F:13][C:14]1[CH:27]=[CH:26][C:17]([C:18]([CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[O:19])=[CH:16][CH:15]=1.[CH2:28]=O>C(O)C>[ClH:12].[F:13][C:14]1[CH:15]=[CH:16][C:17]([C:18]([CH:20]2[CH2:25][CH2:24][N:23]([CH2:28][CH2:1][C:2]3[C:11]4[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=4)[N:5]=[CH:4][N:3]=3)[CH2:22][CH2:21]2)=[O:19])=[CH:26][CH:27]=1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 2415204-MethylquinazolineHCID 3084438p-Fluorophenyl 4-piperidyl ketone hydrochloride

Product 1

HCID 14280682HCID 14280682, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2 g of 4-methylquinazoline was dissolved in 20 ml of ethanol. 3.4 g of 4-(p-fluorobenzoyl)piperidine hydrochloride and 1.9 ml of 37% formalin were added to the solution and the mixture was stirred at room temperature for three days. A white precipitate was recovered by filtration and washed with ethanol to obtain the intended product.

Workup

  1. filtrationA white precipitate was recovered by filtration
  2. washwashed with ethanol
  3. customto obtain the intended product

Sources & evidence

ORD record
ord-240216e6cadc460fa017c1cd36f34d52
Source dataset
uspto-grants-1990_05
Patent number
US04921863

Reaction notes

Loading…