Pyridine → HCID 19854789, compound

HRID 1649784Notes

Reaction equation

HRID 1649784 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Br:13])[N:8]=1.N1C=CC=CC=1>ClCCl>[Br:13][C:9]1[N:8]=[C:7]([NH:6][S:2]([CH3:1])(=[O:4])=[O:3])[CH:12]=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 31297Methanesulfonyl chlorideHCID 3008092-Amino-6-bromopyridine

Product 1

HCID 19854789HCID 19854789, compoundYield 75.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Methanesulphonyl chloride (0.74 g) in dichloromethane (5 ml) was added over 2 min to a stirred solution of 2-amino-6-bromopyridine (1.1 g) and pyridine (0.57 g) in dichloromethane (5 ml). After 4 h, the solvent was evaporated in vacuo to give an oil which was purified by FCC eluting with System A (95:5:1) to give the title compound as a white solid (1.2 g), m.p. 90°-94° C.

Workup

  1. customthe solvent was evaporated in vacuo
  2. customto give an oil which
  3. customwas purified by FCC
  4. washeluting with System A (95:5:1)

Sources & evidence

ORD record
ord-a9ca97b479fe4ed5b07f2412d81f6198
Source dataset
uspto-grants-1990_05
Patent number
US04921867

Reaction notes

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