Sodium Hydroxide → HCID 19854936, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(2-acetoxy-2-methylpropionylamino)-4-[4-(diphenylmethoxy)piperidinomethyl]thiazole (1.1 g), 1N sodium hydroxide (2.2 ml) and ethanol (23 ml) was heated at 40° C. with stirring for 6 hours. The reaction mixture was concentrated under reduced pressure and the residue was extracted with a mixture of chloroform and methanol (10:1 V/V). The extract was washed with a saturated aqueous solution of sodium chloride and dried over magnesium sulfate. The solvent was distilled off and the residue was pulverized with 70% ethanol and collected by filtration. Recrystallization from 70% ethanol gave 2-(2-hydroxy-2-methylpropionylamino)-4-[4-(diphenylmethoxy)piperidinomethyl]thiazole (0.65 g).

Provenance & Evidence