Glycine → HCID 178525876, compound

HRID 1649860Notes

Reaction equation

HRID 1649860 reaction equation
[OH-].[Na+].[NH2:3][CH2:4][C:5]([OH:7])=[O:6].[CH:8]1([CH2:14][NH:15][C:16](=[N:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]([O:28]C)=[O:27])=[CH:22][CH:21]=2)SC)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1>>[CH:8]1([CH2:14][NH:15][C:16](=[N:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]([OH:28])=[O:27])=[CH:22][CH:21]=2)[NH:3][CH2:4][C:5]([OH:7])=[O:6])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 3

HCID 750GlycineHCID 14798Sodium HydroxideHCID 178498152HCID 178498152, compound

Product 1

HCID 178525876HCID 178525876, compoundYield 79%

Procedure

This compound is obtained (yield 79%; melting point 164° C.), by saponification of N-[N-cyclohexylmethylamino(4-caraboxyphenylimino)methyl]-2-aminoethanoic acid (melting point 163° C.) in a 1N sodium hydroxide solution, whereby the former was prepared from glycine and N-cyclohexylmethyl-N'-(4-methoxycarbonylphenyl)-S-methylisothiourea according to the experimental procedure described in Example 2.

Workup

  1. customThis compound is obtained (yield 79%; melting point 164° C.)

Sources & evidence

ORD record
ord-d1b693157f2141cb9f0e526049f424ab
Source dataset
uspto-grants-1990_05
Patent number
US04921939

Reaction notes

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