Methyl iodide → HCID 178503888, compound

Participants

Reaction Steps

Ten grams (59 mmol) of 3-chlorophenyl isothiocyanate and 4.15 g (65 mmol) of monosodium cyanamide are mixed in 100 cm3 of absolute ethanol and kept boiling for 2 hours. After elimination of the solvent, the resulting solid residue is washed with 100 cm3 of ethyl ether. The compound is then suspended in a solution of 4.8 cm3 (77 mmol) of methyl iodide in 50 cm3 of ethanol. The mixture is then left at ambient temperature for 20 hours. The final precipitate is filtered and washed with water (2×50 cm3) and ethanol (2×50 cm3) and is then dried in vacuo. A 10.1 gram portion of N-(3-chlorophenyl)-N'-cyano-S-methylisothiourea is obtained with a melting point of 167° C. ##STR88##

Provenance & Evidence