Glycine → HCID 178510067, compound

Participants

Reaction Steps

A mixture of 0.57 g (7.6 mmoles) of glycine and 0.3 g (7.6 mmoles) of sodium hydroxide in 3 cm3 of water and 2.5 (7.6 mmoles) of N-(4-cyanophenyl)-N'-phenylsulfonyl-S-methylisothiourea in 30 cm3 of 95% ethanol is heated to boiling for 7 hours. After cooling, the precipitate obtained is filtered and dissolved in 20 cm3 of 1N sodium hydroxide solution. The solution obtained is washed with dichloromethane (3×10 cm3) and ethyl acetate (2×10 cm3) and is then acidified to pH 3 with a 6N HCl solution. After cooling, precipitate forms and is filtered, washed with water (2×5 cm3) and dried in vacuo to give 1.4 g (yield 52%) of N-[phenylsulfonylimino(4-cyanophenylamino)methyl]-2-aminoethanoic acid having a melting point of 133° C.

Provenance & Evidence