Glycine → HCID 178505159, compound

Participants

Reaction Steps

A mixture of 0.57 g (7.6 mol) of glycine, of 0.3 g (7.6 mmol) of sodium hydroxide in 3 cm3 of water and of 2.0 g (7.6 mmol) of N-(4-cyanophenyl)-N'-methylsulfonyl-S-methylisothiourea in 30 cm3 of 95% ethanol is heated at boiling point for 7 hours. After cooling, the precipitate obtained is filtered and dissolved in 20 cm3 of a 1N sodium hydroxide solution. The solution obtained is washed with dichloromethane (3×10 cm3) and ethyl acetate (2×10 cm3) then acidified to a pH close to 3 with a 6N HCl solution. After cooling, the precipitate obtained is filtered, washed with water (2×5 cm3) and dried in vacuo to give N-[methylsulfonylimino(4-cyanophenylamino)methyl]-2-aminoethanoic acid (yield 55%) having a melting point of 170° C.

Provenance & Evidence