Ethyl benzenesulfonate → HCID 19855243, compound

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Reaction Steps

21.06 g (0.1 mole) of 3-amino-7-chloro-4-quinoline-thiol are dissolved in 100 ml of a 2 molar sodium hydroxide solution, whereupon 23.30 g (0.125 mole) of ethyl benzene sulfonate are added. The reaction mixture is heated to boiling for 2 hours and the product thus formed is extracted with chloroform. The chloroform solution is clarified with activated charcoal, dried and acidified with alcohol containing hydrogen chloride. Thus 24.0 g of 3-amino-4-ethylthio-7-chloro-quinoline-hydrochloride are obtained. After crystallization from methanol the product melts at 212°-216° C. under decomposition. Yield 85%. The product thus obtained is identical with the compound prepared according to Example 5.

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