Diethyl Sulfate → HCID 15006891, compound

Participants

Reaction Steps

21.06 g (0.1 mole) of 3-amino-7-chloro-4-quinoline-thiol are dissolved in 100 ml of a 2 molar sodium hydroxide solution, whereupon 19.27 g (0.125 mole) of diethyl sulfate are added. The reaction mixture is heated to boiling for 2 hours, cooled to room temperature and extracted with dichloro ethane. The dichloro ethane solution is dried, clarified and evaporated. Thus 20.2 g of 3-amino-4-ethylthio-7-chloro-quinoline are obtained, yield 85%, m.p.: 105°-106° C. (after crystallization from methanol).

Provenance & Evidence