Acetic Acid → 1H-Imidazole, 2-methyl-1-(1-methylethyl)-

HRID 1649887Notes

Reaction equation

[CH:1]([NH:4][CH2:5][CH2:6][NH2:7])([CH3:3])[CH3:2].[C:8](O)(=O)[CH3:9]>>[CH:1]([N:4]1[CH:5]=[CH:6][N:7]=[C:8]1[CH3:9])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 176Acetic Acid

HCID 88098N-Isopropylethylenediamine

Product 1

HCID 146708161H-Imidazole, 2-methyl-1-(1-methylethyl)-

Procedure

The procedure of Example 1 was followed except that 33.1 g (0.32 mol) of N-isopropylethylenediamine, 19.4 g (0.32 mole) of acetic acid and 5.9 g of Harshaw Ni-2715 catalyst were used. About 37.6 g of crude product was recovered. GLC analysis showed that the crude product contained 98% of 1-isopropyl-2-methylimidazole.

Workup

customAbout 37.6 g of crude product was recovered

Sources & evidence

ORD record: ord-e39c2e22189047fda601ce185c7ff57d
Source dataset: uspto-grants-1990_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04921969

Reaction notes

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