HCID 14050520, compound → HCID 141560440, compound

HRID 1649889Notes

Reaction equation

[C:1]([NH:20][C:21]1[S:25][N:24]=[C:23](/[C:26](=[N:30]/[O:31][CH:32]([F:34])[F:33])/[C:27](O)=[O:28])[N:22]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:36][C@@H:37]1[C:60](=[O:61])[N:39]2[C:40]([C:48]([O:50][CH2:51][C:52]3[CH:57]=[CH:56][C:55]([O:58][CH3:59])=[CH:54][CH:53]=3)=[O:49])=[C:41](/[CH:44]=[CH:45]\[CH2:46][Cl:47])[CH2:42][S:43][C@H:38]12>>[C:1]([NH:20][C:21]1[S:25][N:24]=[C:23](/[C:26](=[N:30]/[O:31][CH:32]([F:33])[F:34])/[C:27]([NH:36][C@@H:37]2[C:60](=[O:61])[N:39]3[C:40]([C:48]([O:50][CH2:51][C:52]4[CH:53]=[CH:54][C:55]([O:58][CH3:59])=[CH:56][CH:57]=4)=[O:49])=[C:41](/[CH:44]=[CH:45]\[CH2:46][Cl:47])[CH2:42][S:43][C@H:38]23)=[O:28])[N:22]=1)([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 14050520HCID 14050520, compound

HCID 70101812HCID 70101812, compound

Product 1

HCID 141560440HCID 141560440, compoundYield 88.8%

Procedure

In the same manner as described in Experiment 3, 2-(5-tritylamino-1,2,4-thiadiazol-3-yl)-(Z)-2-difluoromethoxyiminoacetic acid (2.00 g) was reacted with p-methoxybenzyl 7β-amino-3-[(Z)-3-chloro-1-propen-1-yl]-3-cephem-4-carboxylate hydrochloride (1.795 g) to obtain the object product (3.17 g).

Sources & evidence

ORD record: ord-88a9b97d77bd4cf8abb15408e571ce8a
Source dataset: uspto-grants-1990_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04921850

Reaction notes

Loading…