Methanol → HCID 19855450, compound

HRID 1649944Notes

Reaction equation

HRID 1649944 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH:12]2[CH2:21][CH2:20][CH2:19][C:18]3[CH:17]=[C:16]([O:22][CH2:23][C:24](N)=[O:25])[CH:15]=[CH:14][C:13]2=3)(=[O:10])=[O:9])=[CH:4][CH:3]=1.C[OH:28]>[OH-].[K+]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH:12]2[CH2:21][CH2:20][CH2:19][C:18]3[CH:17]=[C:16]([O:22][CH2:23][C:24]([OH:25])=[O:28])[CH:15]=[CH:14][C:13]2=3)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 887Methanol2×HCID 14014988HCID 14014988, compound

Product 1

HCID 19855450HCID 19855450, compound

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent2×

Procedure

10 mmol of 5-(4-chlorobenzenesulphonylamino)-5,6,7,8-tetrahydro-naphth-2-yl-oxyacetamide are heated under reflux in 12 ml of 2N KOH and 40 ml of MeOH for 6 hours. The methanol is stripped off, 30 ml of 1N KOH are added and the mixture is extracted by shaking twice with CH2Cl2. The H2O phase is brought to pH 2 with concentrated HCl and the precipitate is filtered off and dried thoroughly.

Workup

  1. extractionthe mixture is extracted
  2. filtrationthe precipitate is filtered off
  3. customdried thoroughly

Sources & evidence

ORD record
ord-bafa3e13728e45e9b31a1b29996898a8
Source dataset
uspto-grants-1990_05
Patent number
US04921998

Reaction notes

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