反应详情

50 mmol of methyl 5-benzoylamino-5,6,7,8-tetrahydro-naphth-1-yl-oxyacetate are stirred in 60 ml of 1N NaOH and 120 ml of MeOH at room temperature for 6 hours. The methanol is stripped off, the NaOH solution is extracted by shaking with ethyl acetate and the extract is then acidified with 10% strength HCl solution. The acid solution is extracted by shaking 3 times with ethyl acetate or tetrahydrofuran, the extract is dried over Na2SO4 and evaporated and the residue is dried under a high vacuum.

1. extractionthe NaOH solution is extracted
2. extractionThe acid solution is extracted
3. stirringby shaking 3 times with ethyl acetate or tetrahydrofuran
4. dry with materialthe extract is dried over Na2SO4
5. customevaporated
6. customthe residue is dried under a high vacuum