Sodium Hydroxide → HCID 19855560, compound

Participants

Reaction Steps

22.8 g (0.115 moles) of 1-(2,6-dimethylphenyl-amino)-2-chloro-propane, prepared as described in Step (a) of Example 11, are dissolved in 300 ml of ethanol. 50 ml of a 10 n aqueous sodium hydroxide solution are added, and the mixture is boiled for one hour. The mixture is allowed to cool, poured onto 500 ml of ice water, and the resulting mixture is extracted thrice with 100 ml of chloroform, each. The chloroform solutions are combined, washed thrice with 100 ml of water, each, dried over anhydrous magnesium sulfate, and the solvent is evaporated under reduced pressure. The oily residue is distilled under reduced pressure. 15.9 g (86.2%) of 1-(2,6-dimethylphenyl)-2-methyl-aziridine are obtained; b.p.: 70°-74° C./40 Pa.

Provenance & Evidence