Potassium Iodide → HCID 13674821, compound

Participants

Reaction Steps

45.3 g (0.164 moles) of 1-chloro-2-[N-(2,6-dimethylphenyl)-methanesulfonamido]-propane are dissolved in 700 ml of dry dimethyl formamide, 61 g (0.33 moles) of potassium phthalimide and 1 g (6 mmoles) of potassium iodide are added, and the mixture is stirred at 140°-145° C. for 7 hours. The reaction mixture is processed as described in Example 21 for the preparation of the starting substance. The resulting 46.6 g of crude, honey-like substance is triturated with 50 ml of diethyl ether, the separated crystalline substance is filtered off, washed with diethyl ether and dried. 23.05 g of a crystalline substance are obtained; m.p.: 155°-160° C. This substance is purified further by stirring it with 50 ml of diethyl ether at room temperature. Thereafter the crystals are filtered off, washed with diethyl ether and dried. 16.75 g (26.4%) of 1-phthalimido-2-[N-(2,6-dimethylphenyl)-methanesulfonamido]-propane are obtained; m.p.: 188°-190° C.

Provenance & Evidence