Thionyl Chloride → HCID 19855553, compound

Participants

Reaction Steps

4.65 ml (7.7 g, 65 mmoles) of thionyl chloride are added dropwise, at room temperature, to a solution of 14.2 g (50 mmoles) of 1-[N-(2,6-dimethylphenyl)-benzamido]-2-propanol in 100 ml of dry benzene, and the mixture is boiled then for 45 minutes. The solvent is evaporated under reduced pressure, and 30 ml of benzene is distilled off from the residue in order to remove the traces of thionyl chloride. This latter operation is repeated. The solid residue is triturated with n-hexane, the crystalline product is filtered off, washed with n-hexane and dried. 14.3 g (95%) of 1-[N-(2,6-dimethylphenyl)-benzamido]-2-chloro-propane are obtained as a white, crystalline substance; m.p.: 106°-109° C.

Provenance & Evidence