Thionyl Chloride → HCID 19855599, compound

Participants

Reaction Conditions

Reaction Steps

4 ml of thionyl chloride are added to a suspension of 10.0 g (35.1 mmoles) of 1-(2,6-dimethylphenyl-amino)-2-(2hydroxyethylamino)-propane dihydrochloride, prepared as des ribed in Example 49, in 100 ml of dry toluene, and the mixture is stirred at 80° C. for 3 hours and then at 100° C. for one hour. The mixture is cooled, the separated precipitate is filtered off, washed with toluene and dried. 10.1 g (92%) of 1-(2,6-dimethylphenyl-amino)-2-(2-chloro-ethylamino)-propane dihydrochloride are obtained; m.p.: 163°-168° C.

Provenance & Evidence