Sodium Acetate → HCID 13730721, compound

HRID 1650092Notes

Reaction equation

HRID 1650092 reaction equation
[C:1]([C:3]([NH:8][C:9](=[O:15])/[CH:10]=[CH:11]\[C:12]([OH:14])=O)([CH3:7])[CH:4]([CH3:6])[CH3:5])#[N:2].C([O-])(=O)C.[Na+]>C(OC(=O)C)(=O)C>[CH:4]([C:3]([CH3:7])([N:8]1[C:9](=[O:15])[CH:10]=[CH:11][C:12]1=[O:14])[C:1]#[N:2])([CH3:6])[CH3:5]

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 86741235HCID 86741235, compound

Product 1

HCID 13730721HCID 13730721, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A solution of N-(1-cyano-1,2-dimethylpropyl)maleamic acid (595 g, 2.83 mol) in acetic anhydride (3.96 liters) containing sodium acetate (13.72 g, 0.167 mol) is heated under reflux for one hour, cooled and the solvent removed in vacuo. The product is distilled* at 120°-130° C./0.1 mm to give 337 g (63%) of product. *The pot temperature should not excede 200°. Anal. calcd. for C10H12N2O2 : C, 62.49; H, 6.29; N, 14.57. Found: C, 62.32; H, 6.36; N, 14.59.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for one hour
  3. temperaturecooled
  4. customthe solvent removed in vacuo
  5. customis distilled* at 120°-130° C.

Sources & evidence

ORD record
ord-5a593657b6ce4ceabc30670d7a8b684b
Source dataset
uspto-grants-1990_05
Patent number
US04923504

Reaction notes

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