Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → HCID 14780584, compound

Participants

Reaction Steps

2-(Dimethylamino)-4-(4-fluorophenyl)-3-quinolinecarboxaldehyde (4.20 g) is dissolved in 100 ml of dichloromethane and (5.25 g, 1.1 equivalents) of methyl (triphenylphosphoranylidene) acetate is added in one portion. The reaction is stirred at room temperature for three days, evaporated, and the residue eluted through a 3-inch silica column to give 4.60 g of (E)-methyl-3-[2-(dimethylamino)-4-(4-fluorophenyl)-3-quinolinyl]-2-propenoate as an orange solid; 1H NMR (chloroform-d): δ 7.78-6.87 (m, 9H), 5.98 (d, 1H), 3.60 (s, 3H), 2.95 (s, 6H) ppm.

Provenance & Evidence