Hydrochloric Acid → HCID 178479664, compound

Participants

Reaction Steps

93.9 g (0.295 mole) of ethyl 4-benzyloxy-3-hydroxy-2-[(1H-imidazol-4-yl)methyl]-butanoate dissolved in 500 ml of absolute ethanol and 65 ml of a 6.8N ethanolic solution of hydrochloric acid, are subjected to hydrogenolysis in the presence of 5 g of 10% palladium on carbon under a hydrogen pressure of 3.5 bars. The catalyst is then filtered off and the solvent is eliminated at 65° C. under reduced pressure. 67.1 g of 4-hydroxy-3-[(1H-imidazol-4-yl)methyl]-dihydro-2(3H)-furanone hydrochloride are obtained (mixture of diastereoisomers). Practically quantitative yield. The product obtained is used as such in the following step.

Provenance & Evidence