重氮甲烷 → HCID 23053803，化合物

HRID 1650172笔记

反应方程式

HRID 1650172 反应方程式
[OH:1][C:2]1[C:6]2[CH2:7][N:8]([C:11]([O:13][CH3:14])=[O:12])[CH2:9][CH2:10][C:5]=2[S:4][N:3]=1.[N+](=[CH2:17])=[N-]>CCOCC.C(O)C>[CH3:17][O:1][C:2]1[C:6]2[CH2:7][N:8]([C:11]([O:13][CH3:14])=[O:12])[CH2:9][CH2:10][C:5]=2[S:4][N:3]=1

参与物

5

反应物 2

HCID 9550重氮甲烷HCID 178501912HCID 178501912，化合物

产物 1

HCID 23053803HCID 23053803，化合物

试剂、催化剂与溶剂 2

HCID 702乙醇溶剂HCID 3283乙醚溶剂

实验过程

To a solution of 1.60 g (7.5 mmol) of methyl 3-hydroxy-4,5,6,7-tetrahydroisothiazolo[4,5-c]pyridine-5-carboxylate (1)1 in ether (50 ml) and ethanol (2 ml) was added an excess of diazomethane. The mixture was stirred at room temperature for 1 hour, and the excess of diazomethane was destroyed by addition of glacial acetic acid. The mixture was evaporated in vacuo and the residue submitted to column chromatography on silica gel (eluent: toluene-ethyl acetate) yielding 890 mg of the title compound as a colourless oil.

后处理

  1. customthe excess of diazomethane was destroyed by addition of glacial acetic acid
  2. customThe mixture was evaporated in vacuo

来源与证据

ORD记录
ord-15a7fe514c51491892176b709cb2ba3a
来源数据集
uspto-grants-1990_05
专利号
US04923880

反应笔记

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