HuagongsheHuagongshe Chemistry Print Report · For research reference only
6,8-Bis(phenylmethyl)-6,8-diazabicyclo[3.2.2]nonane dihydrochloride → 6,8-Diazabicyclo[3.2.2]nonane 2hcl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6,8-Bis(phenylmethyl)-6,8-diazabicyclo[3.2.2]nonane dihydrochloride | HCID 14774637 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | 6,8-Diazabicyclo[3.2.2]nonane 2hcl | HCID 70377082 | 184.7% |
Reaction Steps
A solution of 20.28 g (53.5 mmol) of 6,8-bis(phenylmethyl)-6,8-diazabicyclo[3.2.2]nonane dihydrochloride in 400 of 2:1 methanol-water was hydrogenated using 2.5 g of 20% Pd/C catalyst. The reaction mixture was filtered and evaporated to dryness. The residue was triturated with 2-propanol and filtered to give 9.84 g of 6,8-diazabicyclo[3.2.2]nonane, dihydrochloride, mp 300°-310° dec (92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04923879 |
| Source dataset | uspto-grants-1990_05 |
| ORD ID | ord-911e7a68f16a4e9cb1a5fb764983af8e |
| Source note | uspto-grants-1990_05 |