HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → 4-Bromo-2-phenoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 5-bromo-2-(bromomethyl)benzoate | HCID 12929136 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Bromo-2-phenoxybenzoic acid | HCID 23053920 | 68.2% |
Reaction Steps
Phenol (8 g, 85 mmole) and potassium carbonate (11.7 g, 85 mmole) in 150 mL of N,N-dimethylformamide was reacted with methyl 4-bromo-α-bromo-2-toluate (20 g, 65 mmole) by the procedure of Example 2, step a and followed with alkaline hydrolysis by the procedure of Example 2, step b to give the crude 4-bromo-2-phenoxybenzoic acid (13 g) which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04923892 |
| Source dataset | uspto-grants-1990_05 |
| ORD ID | ord-cd68484142b44369aeda62d09cff9bf2 |
| Source note | uspto-grants-1990_05 |