Boron trifluoride etherate → Methyl 4-(mercaptomethyl)-2-methyl-1,3-dithiolane-2-butanoate

Participants

Reaction Steps

The title compound was prepared according to the procedure of Example 1 using 1,2,3-trimercaptopropane (5 g, 0.0355 mol), methyl 4-acetylbutyrate (5.1 g, 0.0355 mol) and boron trifluoride etherate (1 ml) in methylene chloride (125 ml). The crude product was chromatographed on silica gel using 5% ethyl acetate/hexane as eluent to give 6.5 g (69%) of product.

Provenance & Evidence