Sodium Iodide → HCID 19853685, compound

Participants

Reaction Steps

To a solution of 23.463 g (125.069 mM) of 2'-amino-2-chloro-5'-fluoroacetophenone in 436 ml of CH3CN is added 56.2 g (375.2 mM) of NaI, and the mixture is stirred at room temperature for 45 min. and concentrated under reduced pressure. The resulting residue is dissolved in ethyl acetate, washed with aqueous Na2S2O3, and brine in order, dried and concentrated to give 29.97 g (Yield: 85.9%) of 2'-amino-5'-fluoro-2-iodoacetophenone as yellow crystals.

Provenance & Evidence