Acetic Anhydride → 2-(2-Formamidothiazol-4-yl)-2-isopropoxyiminoacetic acid

HRID 1650427Notes

Reaction equation

HRID 1650427 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:11][O:12][CH:13]([CH3:15])[CH3:14])[C:8]([OH:10])=[O:9])[N:6]=1.[C:16](OC(=O)C)(=[O:18])C>C(O)=O>[CH:16]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:11][O:12][CH:13]([CH3:15])[CH3:14])[C:8]([OH:10])=[O:9])[N:6]=1)=[O:18]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 541000552-Isopropoxyimino-2-(2-aminothiazol-4-yl)acetic acid

Product 1

HCID 538092752-(2-Formamidothiazol-4-yl)-2-isopropoxyiminoacetic acidYield 83.5%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

2-(2-Aminothiazol-4-yl)-2-iso-propoxyiminoacetic acid (syn isomer, 4 g.), acetic anhydride (7.6 g.) and formic acid (3.4 g.) were treated in a similar manner to that of Example F-(5) to give 2-(2-formamidothiazol-4-yl)-2-iso-propoxyiminoacetic acid (syn isomer, 3.75 g.), mp. 168° to 169° C. (dec.).

Sources & evidence

ORD record
ord-fe94336c88e2483d9be40762a7a716b8
Source dataset
uspto-grants-1990_05
Patent number
US04923998

Reaction notes

Loading…