Methanol → 2-(2-Aminothiazol-4-yl)-2-isobutoxyiminoacetic acid

Participants

Role	Name	HCID	Charge
Reactant	Methanol	HCID 887	—
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	Ethyl 2-(2-aminothiazol-4-yl)-2-iso-butoxyiminoacetate	HCID 53811669	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	2-(2-Aminothiazol-4-yl)-2-isobutoxyiminoacetic acid	HCID 53968178	91.6%

Reaction Steps

Ethyl 2-(2-aminothiazol-4-yl)-2-iso-butoxyiminoacetate (syn isomer, 19.6 g.), 2N aqueous solution of sodium hydroxide (72.2 ml.), methanol (72.2 ml.) and tetrahydrofuran (72.2 ml.) were treated in a similar manner to that of Example F-(4) to give 2-(2-aminothiazol-4-yl)-2-iso-butoxyiminoacetic acid (syn isomer, 16.1 g.), mp 180° C. (dec.).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04923998
Source dataset	uspto-grants-1990_05
ORD ID	ord-29dc8f0861cf4f62898fd4ef4afbd2e9
Source note	uspto-grants-1990_05