HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-Chloro-8-(2,2-diethoxyethoxy)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 5-Chloro-8-hydroxyquinoline | HCID 2817 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethane, 2-bromo-1,1-diethoxy- | HCID 74852 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Chloro-8-(2,2-diethoxyethoxy)quinoline | HCID 14031184 | — |
Reaction Steps
180 g of 5-chloro-8-hydroxyquinoline, 237 g of 2-bromoacetaldehyde diethyl acetal and 200 g of potassium carbonate are stirred for 4 h at 120° C. in 800 ml of dimethylformamide. After cooling, the mixture is poured into 2.5 liters of water, and the product is filtered off under suction and dried in vacuo, melting point 51°-53° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04925478 |
| Source dataset | uspto-grants-1990_05 |
| ORD ID | ord-ee2e93792f0f4c309496a5b499e65c69 |
| Source note | uspto-grants-1990_05 |