Dichloromethane → HCID 19978779, compound

HRID 1650593Notes

Reaction equation

HRID 1650593 reaction equation
BrBr.Cl[CH2:4][CH2:5][CH2:6][C:7](=O)[CH3:8].[C:10]1([SH:16])[CH:15]=[CH:14][CH:13]=[CH:12]C=1.[OH-:17].[K+].[CH2:19](Cl)Cl>CO>[C:8]1([C:14]2([C:13]([CH3:12])=[O:17])[CH2:15][CH:10]2[SH:16])[CH:19]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

7

Reactant 5

HCID 6344Dichloromethane2×HCID 7969ThiophenolHCID 14797Potassium HydroxideHCID 24408BromineHCID 799932-Pentanone, 5-chloro-

Product 1

HCID 19978779HCID 19978779, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 134 g (0.83 mol) of bromine in 130 ml of methylene chloride is added dropwise at 10° C. with stirring to a solution of 100 g (0.83 mol) of 5-chloropentan-2-one in 400 ml of methylene chloride. The reaction mixture is stirred for a further hour at room temperature, then washed using water and dilute aqueous sodium carbonate solution and dried over sodium sulphate. The mixture is concentrated by stripping off the solvent under reduced pressure, the residue is taken up in 200 ml of methanol and 91.5 g (0.83 mol) of thiophenol are added at 5° C. with stirring. A mixture of 93 g of potassium hydroxide powder in 500 ml of methanol is then added dropwise. The reaction mixture is initially stirred for 2 hours at room temperature and then for 4 hours at 40° C. The mixture is then concentrated by stripping off the solvent under reduced pressure and the remaining residue is taken up in methylene chloride. The organic solution is washed successively using water, dilute aqueous sodium hydroxide solution and again using water, then concentrated under reduced pressure and then subjected to a vacuum distillation. In this manner, 76.8 g (48% of theory) of methyl 1-phenyl-mercaptocyclopropyl ketone of boiling point 155° C./20 mbar are obtained.

Workup

  1. washwashed
  2. dry with materialdried over sodium sulphate
  3. concentrationThe mixture is concentrated
  4. stirringwith stirring
  5. additionis then added dropwise
  6. stirringThe reaction mixture is initially stirred for 2 hours at room temperature
  7. concentrationThe mixture is then concentrated
  8. washThe organic solution is washed successively using water, dilute aqueous sodium hydroxide solution and again using water
  9. concentrationconcentrated under reduced pressure
  10. distillationsubjected to a vacuum distillation

Sources & evidence

ORD record
ord-f5fa88ac773044fb951fc38fe2aca41f
Source dataset
uspto-grants-1990_05
Patent number
US04925482

Reaction notes

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