Sodium ethoxide → 4-(4-Pentylbenzyloxy)-2,3-difluorobenzonitrile

Participants

Reaction Steps

A mixture of 0.12 mole of p-pentylbenzyl chloride and 20 ml of ethanol is added to a mixture of 0.1 mole of 2,3-difluoro-4-cyanophenol (prepared as in Example 1) and 0.1 mole of sodium ethoxide in 60 ml of ethanol, and the mixture is heated at the boil for 5 hours. After the ethanol has been distilled off, the reaction mixture is allowed to cool and is poured onto 15 ml of 5% aqueous sodium hydroxide solution. Working up in the customary manner gives 4-(4-pentylbenzyloxy)-2,3-difluorobenzonitrile.

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