Water → HCID 14771648, compound

Participants

Reaction Steps

1-[15-(m-Iodophenyl)pentadecanoyl]-3-O-trityl-rac-glycerol (0.34 g, 0.45 mmol) was dissolved in ethanol free CHCl3 (2.2 ml) in a two-necked flask. Pyridine (0.06 ml, 0.79 mmol) was added, followed by acetyl chloride (0.09 ml, 1.26 mmol). The reaction mixture was stirred for 7 hours, then H2O was added to destroy the excess acetyl chloride. This mixture was diluted with CHCl3, washed twice with 1 N HCl and once with brine. The organic layer was dried over MgSO4 and the solvent was evaporated. Chromatographic purification yielded pure compound 34, 1-[15-(m-iodophenyl)pentadecanoyl]-2-acetyl-3-O-trityl-rac-glycerol. (0.31 g, 86% yield).

Provenance & Evidence