Lawesson's reagent → HCID 14234968, compound

Participants

Reaction Steps

A mixture of 20.0 g (0.0854 mmol) of 6-ethyl-7-methoxy-5-methylimidazo-[1,2-a]pyrimidine-2-carboxamide and 25.4 g (0.0629 mmol) of Lawesson's Reagent in 470 ml of tetrahydrofuran (THF) was refluxed for 4 hours. The mixture was then cooled, and the product was filtered and washed with THF, then ether to obtain 12.06 g (56%) of 6-ethyl-7-methoxy-5-methylimidazo[1,2-a]pyrimidine-2-thiocarboxamide as a yellow solid melting at 248°-259° C.

Provenance & Evidence